Abstract

Short Communication

Brain response in some systemic immune condition-Toxicological aspects

Luisetto M*

Published: 26 December, 2017 | Volume 1 - Issue 1 | Pages: 005-008

From biomedical literature “autism disorder are involved in young patient, that we have abnormalities (Imaging, histology) in some brain areas, and a comples symptomatology. Genetic and environment can produce some unbalances in brain grow and immunitary situation is involved. Apoptotic signal contribute in brain growth and immunologic shock can unbalance the environment producing abnormalities.”

We can see that some pharmacological molecules are been introduced in therapy in some brain pathologies with a specific mechanism: modulating the immune systems. We can see that some systemic immune modifications can unbalance this systems producing pharmacological effect in local place (as Brain). We can observe this phenomena like a kind of toxicity that can be deeply investigate to discover new Pharmacological strategies.

Aim of this work is to observe this kind of pathologies under a specific immune-toxicological aspect. We think that in this field are needed deeply new approach in order to adequately focus this kind of disorder. A different way to set this kind of pathologies can help in searching new pharmacological strategies.

Read Full Article HTML DOI: 10.29328/journal.icci.1001002 Cite this Article Read Full Article PDF

Keywords:

Toxicology; Brain pathology; Immune status; New pharmacological strategies

References

  1. Bilbo SD, Schwarz JM. The immune system and developmental programming of brain and behavior. Neuroendocrinol. 2012; 33:267-286. Ref.: https://goo.gl/W5CicB
  2. Kappos L, Radue EW, O'Connor P, Polman C, Hohlfeld R, et.al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 2010; 362: 387-401. Ref.; https://goo.gl/cm6qn
  3. Luisetto M, Ahmed Yesvi Rafa, Behzad Nili-Ahmadabadi, Farhan Ahmad Khan and Ghulam Rasool Mashori. Immune Shock - Chronologic Event in Some Brain Pathology. Current Opinions in Neurological Science. 1. 2017; 207-215.

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