Perspective
Dendritic cells and TNF-Related apoptosis inducing ligand (TRAIL) represent new possibilities for sepsis treatment
Petya Ganova, Lyudmila Belenska-Todorova and Nina Ivanovska*
Published: 14 November, 2017 | Volume 1 - Issue 1 | Pages: 001-004
Sepsis refers to a generalized inflammatory response of the organism to an infection or to bacterial products in circulation, rather than the development of an infection per se. Despite recent advances in clinical practice and overall medical care, sepsis remains a great health care problem and is still the most common cause of death in critically ill patients with infection. We suppose that during the course of sepsis the expression of TRAIL in different organs correlates with acute mortality and further development of multiple organ dysfunction syndrome (MODS). It is expected that dendritic cells (DCs) might become targets for apoptotic processes in a result of elevated TRAIL expression. This hypothesis is a bias for detailed investigations for in vivo studies in animal models and for in vitro studies of septic patients.
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DOI: 10.29328/journal.hcci.1001001
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References
- Aziz M, Jacob A, Yang WL, Matsuda A, Wang P. Current trends in inflammatory and immunomodulatory mediators in sepsis. J Leukoc Biol. 2013; 93: 329-342. Ref.: https://goo.gl/T8Lre4
- Deutschman CS, Tracey KJ. Sepsis: current dogma and new perspectives. Immunity. 2014; 40: 463-475. Ref.: https://goo.gl/ykFSX8
- Bozza FA, Salluh JI, Japiassu AM, Marcio Soares, Edson F Assis,et al. Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit Care. 2007; 11: 49. Ref.: https://goo.gl/zWRgqj
- Dinarello CA. Historical insights into cytokines. Eur J Immunol. 2007; 37: 34-45. Ref.: https://goo.gl/HVWTvG
- Russell JA. Management of sepsis. N Engl J Med. 2006; 355: 1699-1713. Ref.: https://goo.gl/fs8BRF
- Teijaro JR. Cytokine storms in infectious diseases. Semin Immunopathol. 2017; 39: 501-503. Ref.: https://goo.gl/PsGGJS
- van der Poll T, van de Veerdonk FL, Scicluna BP, Netea MG. The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol. 2017; 17: 407-420. Ref.: https://goo.gl/18HR7r
- Wiersinga WJ, Leopold SJ, Cranendonk DR, van der Poll T. Host innate immune responses to sepsis. Virulence. 2014; 5: 36-44. Ref.: https://goo.gl/CfL6Yy
- Tse MT. Trial watch: Sepsis study failure highlights need for trial design rethink. Nat Rev Drug Discov. 2013; 12: 334. Ref.: https://goo.gl/5z82Lp
- Flohé SB1, Agrawal H, Schmitz D, Gertz M, Flohé S,et al. Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response. J Leukoc Biol. 2006; 79: 473-481. Ref.: https://goo.gl/JWXsZX
- Wu DD, Li T, Ji XY. Dendritic Cells in Sepsis: Pathological Alterations and Therapeutic Implications. J Immunol Res. 2017. Ref.: https://goo.gl/Ya1BYB
- de Aguiar BB, Girardi I, Paskulin DD, de Franca E, Dornelles C,et al. CD14 expression in the first 24h of sepsis: effect of -260C>T CD14 SNP. Immunol Invest. 2008; 37: 752-769. Ref.: https://goo.gl/CT56x1
- Reinhart K1, Glück T, Ligtenberg J, Tschaikowsky K, Bruining A,et al. CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). Crit Care Med. 2004; 32: 1100-1108. Ref.: https://goo.gl/uiQswv
- Schaaf B1, Luitjens K, Goldmann T, van Bremen T, Sayk F, et al. Mortality in human sepsis is associated with downregulation of Toll-like receptor 2 and CD14 expression on blood monocytes. Diagn Pathol. 2009 ;4: 12. Ref.: https://goo.gl/isro1J
- Cristofaro P, Opal SM. The Toll-like receptors and their role in septic shock. Expert Opin Expert Opin Ther Targets. 2003; 7: 603-612. Ref.: https://goo.gl/NpxSmk
- Chaudhry H, Zhou J, Zhong Y, Ali MM, McGuire F, et al. Role of cytokines as a double-edged sword in sepsis. In Vivo. 2013; 27: 669-684. Ref.: https://goo.gl/NDQzoU
- Gogos CA, Drosou E, Bassaris HP, Skoutelis A. Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J Infect Dis. 2000; 181: 176-180. Ref.: https://goo.gl/4roqgz
- Wen H, Hogaboam CM, Gauldie J, Kunkel SL, et al. Severe sepsis exacerbates cell-mediated immunity in the lung due to an altered dendritic cell cytokine profile. Am J Pathol. 2006; 168: 1940-1950. Ref.: https://goo.gl/V9mktc
- Hotchkiss RS, Tinsley KW, Swanson PE, Grayson MH, Osborne DF, et al. Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol. 2002; 168: 2493-2500. Ref.: https://goo.gl/Gna8r2
- Mera S, Tatulescu D, Cismaru C, Bondor C, Slavcovici A, et al. Multiplex cytokine profiling in patients with sepsis. APMIS. 2011; 119: 155-163. Ref.: https://goo.gl/VxmKoi
- Efron PA, Martins A, Minnich D, Tinsley K, Ungaro R,et al. Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis. J Immunol. 2004; 173: 3035-3043. Ref.: https://goo.gl/orCkgy
- Strother RK, Danahy DB, Kotov DI, Kucaba TA, Zacharias ZR, et al. Polymicrobial Sepsis Diminishes Dendritic Cell Numbers and Function Directly Contributing to Impaired Primary CD8 T Cell Responses In Vivo. J Immunol. 2016; 197: 4301-4311. Ref.: https://goo.gl/Aid1YL
- Tinsley KW, Grayson MH, Swanson PE, Drewry AM, Chang KC,et al. Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. J Immunol. 2003; 171: 909-914. Ref.: https://goo.gl/5FpcHr
- Boomer JS, To K, Chang KC, Takasu O, Osborne DF, et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA. 2011; 306: 2594-2605. Ref.: https://goo.gl/N8hZjs
- Fattahi F, Ward PA. Understanding Immunosuppression after Sepsis. Immunity. 2017; 47: 3-5. Ref.: https://goo.gl/vWQAGP
- Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A. Leukocyte apoptosis and its significance in sepsis and shock. J Leukoc Biol. 2005; 78: 325-337. Ref.: https://goo.gl/jPBA1S
- Bayir H, Kagan VE. Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis--there is nothing more practical than a good theory. Crit Care. 2008; 12: 206. Ref.: https://goo.gl/YHgvrb
- Schneider P, Olson D, Tardivel A, Browning B, Lugovskoy A, et al. Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Biol Chem. 2003; 278: 5444-5454. Ref.: https://goo.gl/ommdrh
- Daniels RA, Turley H, Kimberley FC, Liu XS, Mongkolsapaya J, et al. Expression of TRAIL and TRAIL receptors in normal and malignant tissues. Cell Res. 2005; 15: 430-438. Ref.: https://goo.gl/FFijMj
- Delano MJ, Ward PA. Sepsis-induced immune dysfunction: can immune therapies reduce mortality? J Clin Invest. 2016; 126: 23-31. Ref.: https://goo.gl/ks4Bmc
- Hotchkiss RS, Monneret G, Payen D. Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis. 2013; 13: 260-268. Ref.: https://goo.gl/EwjWsC